Microwave-assisted synthesis of bis-Schiff bases of isatin derivatives catalyzed by Maghnite-H⁺ as a green acid catalyst

Authors

  • Boumadiene Benlahreche
  • Assya Taleb3, Khaled Briki
  • Mouna Souad Abbassi
  • Abdelkader Brahimi
  • Saliha Brahimi
  • Mokhtar B. Lahrech
  • Salih Hacini

DOI:

https://doi.org/10.22399/ijcesen.5483

Keywords:

Green synthesis, Bis-Schiff bases of isatin, Maghnite-H+, Microwave-assisted

Abstract

In the present study, we describe a microwave-assisted solvent free synthesis of bis-Schiff bases of isatin derivatives catalyzed by Maghnite-H+. Treatment of isatin with hydrazine monohydrate gives in a first step 3-hydrazonoindolin-2-one, that is isolated and condensed with appropriate aldehydes or ketones in the second step. The major advantages of this unconventional bis-Schiff bases of isatin synthesis are short reaction time, operational simplicity, high yield, easy workup and environment friendly procedure. In addition, the green catalyst could be removed from the reation mixture by simple filtration. The chemical structures of the synthesized compounds were characterized by IR, 1H-NMR and 13C-NMR spectral data and compared  with literature results.

References

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Published

2026-08-16

How to Cite

Boumadiene Benlahreche, Assya Taleb3, Khaled Briki, Mouna Souad Abbassi, Abdelkader Brahimi, Saliha Brahimi, Mokhtar B. Lahrech, & Salih Hacini. (2026). Microwave-assisted synthesis of bis-Schiff bases of isatin derivatives catalyzed by Maghnite-H⁺ as a green acid catalyst. International Journal of Computational and Experimental Science and Engineering, 12(3). https://doi.org/10.22399/ijcesen.5483

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Vol. 12 No. 3 (2026): IJCESEN

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Research Article

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