Enamino ester synthesis using a proton exchanged Algerian montmorillonite clay as acid eco-friendly catalyst
DOI:
https://doi.org/10.22399/ijcesen.4299Keywords:
β-enamino ester, alkyl amines, aromatic amines, β-cetoesters, Maghnite-H+Abstract
An efficient and straightforward methodology has been developed for the synthesis of β-enamino ester derivatives (3a-h). This transformation involves the direct condensation of alkyl or aromatic amines (2a-d) with β-ketoesters (1a-b), facilitated by protonated Algerian montmorillonite clay (MMT-H+) as a heterogeneous, eco-friendly catalyst. The protocol yields the target products in good to excellent yields.The key advantage of this method lies in the utilization of the MMT-H+ catalyst, which is notable for its natural abundance, low cost, and non-toxic nature. As a solid acid, it simplifies the work-up procedure and can be recovered and reused over several cycles without a significant decrease in its catalytic performance. This approach, characterized by its operational simplicity, cost-effectiveness, and environmental friendliness, represents a sustainable alternative for the preparation of these valuable synthetic intermediates.
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