Dosimetric comparison of 3D-Conformal and IMRT techniques used in radiotherapy of gastric cancer: A retrospective study

Authors

  • osman vefa gul
  • hikmettin Demir
  • Gul Kanyilmaz
  • Tahir Cakır

DOI:

https://doi.org/10.22399/ijcesen.296

Keywords:

Gastric cancer, Radiotherapy, 3D-CRT, IMRT

Abstract

This study aimed to compare three-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT) planning techniques commonly used in gastric cancer radiotherapy with dose volume histograms. Computed tomography (CT) images of 20 gastric cancer patients were retrospectively analyzed. 3D-CRT, 5F- IMRT and 7F- IMRT treatment plans were created for each patient. The 3 plans were compared on dose volume histogram (DVH). 3D-CRT, 5F-IMRT and 7F-IMRT plans achieved a prescribed dose of 45 Gy for 95% of PTV volume. D95 values were 45.06±0.47 Gy for 3DCRT, 46.39±0.38 Gy for 5F-IMRT and 45.20±0.11 Gy for 7F-IMRT. In 3D-CRT, 5F-IMRT and 7F-IMRT techniques, the 13 Gy receiving volumes of the right kidney were found to be 35.08+9.59, 36.25+7.97 and 37.03+9.03 respectively. Moreover, the volume of the right kidney receiving a 20 Gy and 30 Gy dose received less dose with 5F-IMRT than with 7F-IMRT. Since each patient's critical organs are at different distances from the target and each technique has its own advantages in terms of critical organs, we suggest that the useful technique should be decided by clinical consensus.

References

Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021). Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 71(3), 209-249. doi:10.3322/caac.21660

Ilic, M., & Ilic, I. (2022). Epidemiology of stomach cancer. World Journal of Gastroenterology, 28(12), 1187-1203. doi:10.3748/wjg.v28.i12.1187

Arnold, M., Abnet, C. C., Neale, R. E., Vignat, J., Giovannucci, E. L., McGlynn, K. A., & Bray, F. (2020). Global Burden of 5 Major Types of Gastrointestinal Cancer. Gastroenterology, 159(1), 335-349.e315. doi:10.1053/j.gastro.2020.02.068

Chu, R. F., Hussien, A., Li, Q. K., Wang, J., Friedes, C., Ferro, A., . . . Voong, K. R. (2020). Radiologic response of chemotherapy alone versus radiation and chemotherapy in the treatment of locally‐advanced or advanced thymic epithelial tumors. Thoracic Cancer, 11(10), 2924-2931. doi:10.1111/1759-7714.13635

Huber, R. M., Flentje, M., Schmidt, M., Pöllinger, B., Gosse, H., Willner, J., & Ulm, K. (2006). Simultaneous Chemoradiotherapy Compared With Radiotherapy Alone After Induction Chemotherapy in Inoperable Stage IIIA or IIIB Non–Small-Cell Lung Cancer: Study CTRT99/97 by the Bronchial Carcinoma Therapy Group. Journal of Clinical Oncology, 24(27), 4397-4404. doi:10.1200/jco.2005.05.4163

Hallissey, M. T., Dunn, J. A., Ward, L. C., Allum, W. H., & British Stomach Cancer, G. (1994). The second British Stomach Cancer Group trial of adjuvant radiotherapy or chemotherapy in resectable gastric cancer: five-year follow-up. The Lancet, 343(8909), 1309-1312. doi:10.1016/s0140-6736(94)92464-3

Zhu, W.-g., Xua, D.-f., Pu, J., Zong, C.-d., Li, T., Tao, G.-z., . . . Ding, J.-x. (2012). A randomized, controlled, multicenter study comparing intensity-modulated radiotherapy plus concurrent chemotherapy with chemotherapy alone in gastric cancer patients with D2 resection. Radiotherapy and Oncology, 104(3), 361-366. doi:10.1016/j.radonc.2012.08.024

Sindelar, W. F., Kinsella, T. J., Tepper, J. E., DeLaney, T. F., Maher, M. M., Smith, R., . . . Glatstein, E. (1993). Randomized trial of intraoperative radiotherapy in carcinoma of the stomach. The American Journal of Surgery, 165(1), 178-187. doi:10.1016/s0002-9610(05)80423-4

Wood, D. E. (2015). National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines for Lung Cancer Screening. Thorac Surg Clin, 25(2), 185-197. doi:10.1016/j.thorsurg.2014.12.003

Yavuz, B. B., Kanyılmaz, G., Aktan, M., & Koç, M. (2018). Mide Kanserli Hastalarda Prognozda Tümör Boyutu Etkin mi? Selcuk Tip Dergisi, 2(34), 51-54. doi:10.30733/std.2018.01001

Chuang, E. Y., Li, G., Wang, J., Hu, W., & Zhang, Z. (2015). Radiation-Induced Liver Injury in Three-Dimensional Conformal Radiation Therapy (3D-CRT) for Postoperative or Locoregional Recurrent Gastric Cancer: Risk Factors and Dose Limitations. Plos One, 10(8). doi:10.1371/journal.pone.0136288

McCollough, C., Bakalyar, D. M., Bostani, M., Brady, S., Boedeker, K., Boone, J. M., . . . Wang, J. (2014). Use of Water Equivalent Diameter for Calculating Patient Size and Size-Specific Dose Estimates (SSDE) in CT: The Report of AAPM Task Group 220. AAPM Rep, 2014, 6-23. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/27546949

Chen, Y.-C., Lin, J.-C., Liu, W.-H., Huang, S.-F., Chou, Y.-C., Li, M.-H., & Tsai, J.-T. (2019). Comparing treatment plans for proximal and middle/distal stomach cancer: intensity-modulated radiotherapy, volumetric-modulated arc therapy, and tomotherapy. Therapeutic Radiology and Oncology, 3, 4-4. doi:10.21037/tro.2018.12.05

Huang, S.-F., Lin, J.-C., Shiau, A.-C., Chen, Y.-C., Li, M.-H., Tsai, J.-T., & Liu, W.-H. (2020). Optimal tumor coverage with different beam energies by IMRT, VMAT and TOMO. Medicine, 99(47). doi:10.1097/md.0000000000023328

Li, M., Dou, W., Lin, Y., Li, Q., Xu, H., & Zhang, D. (2021). Evidence Mapping of Proton Therapy, Heavy Ion Therapy, and Helical Tomotherapy for Gastric Cancer. Oncology Research and Treatment, 44(12), 700-709. doi:10.1159/000518997

Zhang, T., Liang, Z. W., Han, J., Bi, J. P., Yang, Z. Y., & Ma, H. (2015). Double-arc volumetric modulated therapy improves dose distribution compared to static gantry IMRT and 3D conformal radiotherapy for adjuvant therapy of gastric cancer. Radiat Oncol, 10, 114. doi:10.1186/s13014-015-0420-x

Serarslan, A., Ozbek Okumus, N., Gursel, B., Meydan, D., Dastan, Y., & Aksu, T. (2017). Dosimetric Comparison of Three Different Radiotherapy Techniques in Antrum-Located Stomach Cancer. Asian Pac J Cancer Prev, 18(3), 741-746. doi:10.22034/APJCP.2017.18.3.741

Ma, H., Han, J., Zhang, T., & Ke, Y. (2013). Comparison of dosiology between three dimensional conformal and intensity-modulated radiotherapies (5 and 7 fields) in gastric cancer post-surgery. Journal of Huazhong University of Science and Technology [Medical Sciences], 33(5), 759-764. doi:10.1007/s11596-013-1193-9

Inan, G., & Gul, O. V. (2021). Comparing treatment plans for stomach cancer: three-dimensional conformal radiotherapy (3D-CRT), physical wedge-based conformal RT (WB-CRT) and intensity-modulated radiotherapy (IMRT). Journal of Radiotherapy in Practice, 21(3), 303-308. doi:10.1017/s146039692000118

Çakır, T., G. Yılmazer, and T. Tuğrul, Dosimetric comparison of 3D-conformal and IMRT radiotherapy techniques in gastric cancer. Eastern Journal of Medicine, 2019. 24(3): p. 299-302

Bektas, K., & Kuzhan, A. (2023). Comprasion of dose distribution for critical organs with intensity modulated radiotherapy and 3D Conformal radiotherapy for gastric cancer : Intensity modulated radiation therapy in gastric cancer. Journal on Mathematic, Engineering and Natural Sciences (EJONS), 7(2), 252–256. https://doi.org/10.5281/zenodo.8266644

Downloads

Published

2024-02-18

How to Cite

gul, osman vefa, Demir, hikmettin, Kanyilmaz, G., & Cakır, T. (2024). Dosimetric comparison of 3D-Conformal and IMRT techniques used in radiotherapy of gastric cancer: A retrospective study . International Journal of Computational and Experimental Science and Engineering, 10(1). https://doi.org/10.22399/ijcesen.296

Issue

Section

Research Article